Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Developing phage therapy that overcomes the evolution of bacterial resistance

A Oromí-Bosch, JD Antani… - Annual Review of Virology, 2023 - annualreviews.org
The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

[HTML][HTML] Bacteriophage-encoded enzymes destroying bacterial cell membranes and walls, and their potential use as antimicrobial agents

Ł Grabowski, K Łepek, M Stasiłojć… - Microbiological …, 2021 - Elsevier
Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

Bacteriophages as additives in edible films and coatings

MC García-Anaya, DR Sepulveda… - Trends in Food Science …, 2023 - Elsevier
Background The advent of new technologies aimed at ensuring the food safety has
increased in recent years. This trend has promoted the manufacturing of edible films and …

The human gut virome: composition, colonization, interactions, and impacts on human health

E Pargin, MJ Roach, A Skye, B Papudeshi… - Frontiers in …, 2023 - frontiersin.org
The gut virome is an incredibly complex part of the gut ecosystem. Gut viruses play a role in
many disease states, but it is unknown to what extent the gut virome impacts everyday …

Bacteriophages as biotechnological tools

MA Elois, R Silva, GVT Pilati, D Rodríguez-Lázaro… - Viruses, 2023 - mdpi.com
Bacteriophages are ubiquitous organisms that can be specific to one or multiple strains of
hosts, in addition to being the most abundant entities on the planet. It is estimated that they …

A phage foundry framework to systematically develop viral countermeasures to combat antibiotic-resistant bacterial pathogens

VK Mutalik, AP Arkin - Iscience, 2022 - cell.com
At its current rate, the rise of antimicrobial-resistant (AMR) infections is predicted to paralyze
our industries and healthcare facilities while becoming the leading global cause of loss of …

Bacteriophages in nature: recent advances in research tools and diverse environmental and biotechnological applications

M Bisen, K Kharga, S Mehta, N Jabi… - Environmental Science and …, 2024 - Springer
Bacteriophages infect and replicate within bacteria and play a key role in the environment,
particularly in microbial ecosystems and bacterial population dynamics. The increasing …

Evolution of bacteriophage latent period length

ST Abedon - … Biology: Contemporary and Historical Reflections Upon …, 2023 - Springer
The life cycles of bacterial viruses—known as bacteriophages or phages—alternate
between the infection of individual cells, creating “virocells,” and phage existence instead as …