Importance Osteoarthritis (OA) is the most common joint disease, affecting an estimated
more than 240 million people worldwide, including an estimated more than 32 million in the …

Background Chronic pain is common in adults, and often has a detrimental impact upon
physical ability, well‐being, and quality of life. Previous reviews have shown that certain …

Objective: We conducted the updated systematic review and meta-analysis of the best
available quantitative and qualitative evidence to evaluate the effects and safety of …

Spinal cord injuries (SCIs) are among the most traumatic events worldwide, which often
cause disabilities in patients, affecting and reducing the quality of life [1, 2]. These spinal …

Objective Symptomatic knee osteoarthritis (SKOA) is a chronic, disabling condition, requiring
long‐term pain management; over 800,000 SKOA patients in the US use opioids on a …

Objectives Pain is the prevailing symptom of knee osteoarthritis. Central sensitisation
creates discordance between pain and joint pathology. We previously reported a Central …

For patients with osteoarthritis (OA) of the knee, pain is the most debilitating symptom.
Although it has been proposed that the chronic phase of the monoiodoacetate (MIA) …

Objective Pharmacotherapy is the most common strategies to reduce pain for osteoarthritis
(OA) patients. To analyze the trend and pattern of prescription analgesic medication use in …

This study investigated the tolerability and preliminary efficacy of duloxetine as an
alternative nonopioid therapeutic option for the prevention of persistent musculoskeletal …

Chronic pain begins with acute pain. Physicians tend to classify pain by duration (acute vs
chronic) and mechanism (nociceptive, neuropathic and nociplastic). Although this taxonomy …