This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

Cancer is a major cause of death worldwide. MET tyrosine kinase receptor [MET, c-MET,
hepatocyte growth factor (HGF) receptor] pathway activation is associated with the …

Aberrant activation of Notch signaling plays an oncogenic role in cancer development.
Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell …

Abstract Background The Hippo pathway is widely considered to inhibit cell growth and play
an important role in regulating the size of organs. However, recent studies have shown that …

Gastric cancer remains a disease with a dismal prognosis. Extensive efforts to find
targetable disease drivers in gastric cancer were implemented to improve patient outcomes …

Mesenchymal stem/stromal cells (MSCs) regulate immunity through myeloid-derived
suppressor cells (MDSCs), which are a heterogeneous population of immature myeloid cells …

The present study was designed to investigate the role and mechanism of action behind the
action of lidocaine in gastric cancer cells. Lidocaine was tested for its potential role in …

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

One of the most important issues in cancer progression is caner stem cells (CSCs) which
have illustrated that the bulk tumors can arise from a special combination of cells …

Receptor tyrosine kinases are involved in essential signaling roles that impact cell growth,
differentiation, and proliferation. The overexpression or mutation of these proteins can lead …