Early Empirical Use of Broad-Spectrum Antibiotics in Sepsis

JL Chang, JC Pearson, C Rhee - Current Infectious Disease Reports, 2022 - Springer
Abstract Purpose of Review Early antibiotic administration is the cornerstone of sepsis
treatment guidelines and quality measures. We summarize recent key literature on sepsis …

Association between emergency department sepsis order set design and delay to second dose piperacillin-tazobactam administration

RM Erickson, GL Sacha, SR Bauer, BS Fertel… - The American journal of …, 2023 - Elsevier
Background Delay to first antibiotic dose in patients with sepsis has been associated with
increased mortality. Second dose antibiotic delay has also been linked to worsened patient …

Implementation of an electronic alert to improve timeliness of second dose antibiotics for patients with suspected serious infections in the emergency department: a …

AH Lee, DS McEvoy, T Stump, R Stevens… - Annals of Emergency …, 2023 - Elsevier
Study objective Delays in the second dose of antibiotics in the emergency department (ED)
are associated with increased morbidity and mortality in patients with serious infections. We …

Impact of extended emergency department stay on antibiotic re-dosing delays and outcomes in sepsis

TL Harpenau, SN Bhatti, BM Hoffman… - The American Journal of …, 2022 - Elsevier
Background For patients with sepsis and septic shock, the initial administration of antibiotics
should occur as soon as possible, preferably within one hour of sepsis recognition. While …

Prevalence, risk factors, and outcomes associated with delayed second doses of antibiotics in sepsis at a large academic medical center

ME Cook, BR Schuler, MJ Schontz… - Antimicrobial …, 2023 - cambridge.org
Objective: To evaluate the prevalence, risk factors, and clinical impact of delays in second
doses of antibiotics in patients with sepsis. Design: Single-center, retrospective …

Evaluation of the impact of a pharmacist-run antimicrobial report in reducing delays in subsequent antibiotic administration in patients in the emergency department

M Moynihan, G Anton - American Journal of Health-System …, 2023 - academic.oup.com
Purpose To determine whether the implementation of a pharmacist-run, real-time electronic
health record (EHR) antimicrobial report reduces the frequency of delays in subsequent …

The Relationship Between First-Dose Antibiotic Delay Intervals and In-Hospital Mortality in Patients with Sepsis

C Zhang, H Huang, Z Bai - Human Biology, 2024 - humbiol.org
Background: Early antimicrobial therapy is the cornerstone for the treatment of sepsis,
although the time targets of antibiotic delivery are unknown. Objectives: In this study, we …

[引用][C] Emergency Evaluation and Management of Sepsis and Septic Shock

K Dillon - Physician Assistant Clinics, 2023 - physicianassistant.theclinics.com
In 2016, the Sepsis Task Force revised the accepted definition of sepsis as lifethreatening
organ dysfunction characterized by a dysregulated host response to infection. 1, 2 Septic …