The novel coronavirus SARS-CoV-2 was identified as the causative agent for a series of
atypical respiratory diseases in the Hubei Province of Wuhan, China in December of 2019 …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Increased pulmonary vascular permeability due to endothelial cell (EC) barrier dysfunction
is a major pathological feature of acute respiratory distress syndrome/acute lung injury …

The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption
after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …