Endothelial–mesenchymal transition in atherosclerosis
C Souilhol, MC Harmsen, PC Evans… - Cardiovascular …, 2018 - academic.oup.com
Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the
wall of arteries and the formation of plaques, which comprise immune cells, mesenchymal …
wall of arteries and the formation of plaques, which comprise immune cells, mesenchymal …
Cell–matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues
JH Chen, CA Simmons - Circulation research, 2011 - Am Heart Assoc
The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur
in the organization, composition, and mechanical properties of the extracellular matrix …
in the organization, composition, and mechanical properties of the extracellular matrix …
Biomechanical factors in the biology of aortic wall and aortic valve diseases
The biomechanical factors that result from the haemodynamic load on the cardiovascular
system are a common denominator of several vascular pathologies. Thickening and …
system are a common denominator of several vascular pathologies. Thickening and …
Aortic valve disease and treatment: the need for naturally engineered solutions
JT Butcher, GJ Mahler, LA Hockaday - Advanced drug delivery reviews, 2011 - Elsevier
The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …
arterial system. The natural anatomical geometry and microstructural complexity ensures …
Serotonin receptors and heart valve disease—it was meant 2B
Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …
[HTML][HTML] Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
Hemodynamics and mechanobiology of aortic valve inflammation and calcification
K Balachandran, P Sucosky… - International journal of …, 2011 - Wiley Online Library
Cardiac valves function in a mechanically complex environment, opening and closing close
to a billion times during the average human lifetime, experiencing transvalvular pressures …
to a billion times during the average human lifetime, experiencing transvalvular pressures …
Potential drug targets for calcific aortic valve disease
Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …
mortality and, given its association with age, the prevalence of CAVD is expected to continue …
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve
K Balachandran, PW Alford… - Proceedings of the …, 2011 - National Acad Sciences
Endothelial-mesenchymal transformation (EMT) is a critical event for the embryonic
morphogenesis of cardiac valves. Inducers of EMT during valvulogenesis include VEGF …
morphogenesis of cardiac valves. Inducers of EMT during valvulogenesis include VEGF …
Basic mechanisms of calcific aortic valve disease
P Mathieu, MC Boulanger - Canadian Journal of Cardiology, 2014 - Elsevier
Calcific aortic valve disease (CAVD) is the most common heart valve disorder. There is no
medical treatment to prevent and/or promote the regression of CAVD. Hence, it is of foremost …
medical treatment to prevent and/or promote the regression of CAVD. Hence, it is of foremost …