Inflammation and its timely resolution are critical to ensure effective host defense and
appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation …

Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty …

Diabetic kidney disease (DKD) is a common complication of diabetes and has become the
leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and …

We discuss the fascinating pharmacology of formylpeptide receptor 2 (FPR2; often referred
to as FPR2/ALX since it binds lipoxin A4). Initially identified as a low‐affinity 'relative'of …

Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that
leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal …

Background Damage to the cerebral vasculature can lead to vascular contributions to
cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to …

Background Endothelial injury caused by Type 2 diabetes mellitus (T2DM) is considered as
a mainstay in the pathophysiology of diabetic vascular complications (DVCs). However, the …

Diabetic kidney disease (DKD) is a common microangiopathy in diabetic patients and the
main cause of death in diabetic patients. The main manifestations of DKD are proteinuria …