Suicidal behavior across a broad range of psychiatric disorders

YE Xu, DA Barron, K Sudol, S Zisook… - Molecular …, 2023 - nature.com
Suicide is a leading cause of death worldwide. In 2020, some 12.2 million Americans
seriously contemplated suicide, 3.2 million planned suicide attempts, and 1.2 million …

Plasticity of synapses and reward circuit function in the genesis and treatment of depression

SM Thompson - Neuropsychopharmacology, 2023 - nature.com
What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors

AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …

Genome-wide association study meta-analysis of suicide death and suicidal behavior

QS Li, AA Shabalin, E DiBlasi, S Gopal… - Molecular …, 2023 - nature.com
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …

Identification of novel, replicable genetic risk loci for suicidal thoughts and behaviors among US military veterans

NA Kimbrel, AE Ashley-Koch, XJ Qin… - JAMA …, 2023 - jamanetwork.com
Importance Suicide is a leading cause of death; however, the molecular genetic basis of
suicidal thoughts and behaviors (SITB) remains unknown. Objective To identify novel …

Biological factors underpinning suicidal behaviour: an update

MN Abou Chahla, MI Khalil, S Comai, L Brundin… - Brain sciences, 2023 - mdpi.com
Suicide, a global health burden, represents the 17th leading cause of death worldwide
(1.3%), but the 4th among young people aged between 15 and 29 years of age, according to …

Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations

S Mirza, AR Docherty, A Bakian, H Coon… - American Journal of …, 2022 - Wiley Online Library
Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent
need to advance research on its phenomenology and etiology. Epidemiological studies …

[HTML][HTML] How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide

X Gonda, P Dome, G Serafini, M Pompili - Pharmacology & Therapeutics, 2023 - Elsevier
The impact of suicide on our societies, mental healthcare, and public health is beyond
questionable. Every year approximately 700 000 lives are lost due to suicide around the …

Developing and implementing predictive models in a learning healthcare system: traditional and artificial intelligence approaches in the Veterans Health …

D Atkins, CA Makridis, G Alterovitz… - Annual Review of …, 2022 - annualreviews.org
Predicting clinical risk is an important part of healthcare and can inform decisions about
treatments, preventive interventions, and provision of extra services. The field of predictive …

Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans

NA Kimbrel, ME Garrett, MK Evans, C Mellows… - Frontiers in …, 2023 - frontiersin.org
Introduction The US suicide mortality rate has steadily increased during the past two
decades, particularly among military veterans; however, the epigenetic basis of suicidal …