Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and
perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic …

This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …

ContextThe effect of antihypertensive drugs on cardiovascular events in patients with
coronary artery disease (CAD) and normal blood pressure remains uncertain. ObjectiveTo …

The human intestinal absorption of 241 drugs was evaluated. Three main methods were
used to determine the human intestinal absorption: bioavailability, percentage of urinary …

The intestinal epithelium is a major barrier to the absorption of hydrophilic drugs. The
presence of intercellular junctional complexes, particularly the tight junctions (zona …

Understanding the mechanism of action and the pharmacokinetic properties of vasodilatory
drugs facilitates optimal use in clinical practice. It should be kept in mind that a drug belongs …

The pharmacokinetic and pharmacodynamic properties of nonpeptide angiotensin
antagonists in humans are reviewed in this paper. Representatives of this new therapeutic …

The prevalence of orthostatic hypotension in the elderly is reported to be 5 to 33%. This high
prevalence contributes to the risk of syncope and falls in old age. Drugs are a major cause of …

Highlights•Pharmacokinetics data are too limited to support an age-related effect on
enalapril.•Moderate strong evidence supports enalapril's efficacy in older hypertensive …

Although intestinal metabolism plays an important role in drug disposition, early predictions
of human outcomes are challenging, in part because of limitations of available in vitro …