Ethanol (alcohol) is one of the most widely used legal drugs in the world. Ethanol is
metabolized by alcohol dehydrogenase (ADH) and the cytochrome P450 (CYP) 2E1 drug …

Proton pump inhibitors (PPIs) are the first-choice drugs used to prevent and treat acid-
related diseases. However, a lack of satisfactory response to the standard PPI dose (“PPI …

A reliable method for the quantitative analysis of ethanol in microvolumes (50–100 μL) of
blood became available in 1922, making it possible to investigate the absorption …

Computational models of drug metabolism prediction have focused mainly on cytochrome
P450 enzymes, because drug–drug interactions, reactive metabolite formation …

Therapeutic drug monitoring is useful for individual dosage adjustment and avoiding drug
toxicity for certain drugs with narrow therapeutic window. However, only relatively few drugs …

Chemistry. Our survey encompasses the period from January 1997 through December
1998. Because of the normal delays in the abstraction of journal articles by Chemical …

ABSTRACT Introduction: In the 1980s–1990s numerous studies were performed on H2-
receptor antagonist inhibition of ethanol first-pass metabolism. Blood alcohol concentrations …

antagonists are commonly prescribed drugs and alcohol use is widespread in the
community. Any possible interaction may be important because of the frequent co …

In the UK, the maximal permitted ethanol concentration for driving is 80 mg ethanol/100 mL
blood, 35 μg ethanol/100 mL breath or 107 mg ethanol/100 mL urine. Drivers exceeding the …

Ethanol acts as a depressant of the central nervous system and impairs cognitive and
psychomotor functioning in a dose-dependent manner depending on the blood-alcohol …