Evaluation of the therapeutic effects of arbutin on cisplatin‐induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although
cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including …
cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including …
Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection
F Dai, H Liu, J He, J Wu, C Yuan, R Wang… - Stem Cell Research & …, 2024 - Springer
Background Clinically, hormone replacement therapy (HRT) is the main treatment for
primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast …
primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast …
Pharmacological and biochemical insights into lead-induced hepatotoxicity: Pathway interplay and the protective effects of arbutin via the oral and intraperitoneal …
AA Elhemiely, A Darwish - International Immunopharmacology, 2024 - Elsevier
Abstract Introduction Lead acetate (PbAc), a hazardous heavy metal, poses significant
threats to human health and the environment because of widespread industrial exposure …
threats to human health and the environment because of widespread industrial exposure …
[HTML][HTML] Targeting JAK2/STAT3, NLRP3/Caspase-1, and PK2/PKR2 Pathways with Arbutin Ameliorates Lead Acetate-Induced Testicular Injury in Rats
The reproductive system of males is adversely impacted by lead (Pb), a toxic heavy metal.
The present study examined arbutin, a promising hydroquinone glycoside, for its potential …
The present study examined arbutin, a promising hydroquinone glycoside, for its potential …
Piperine mitigates oxidative stress, inflammation, and apoptosis in the testicular damage induced by cyclophosphamide in mice
F Fani, SJ Hosseinimehr, M Zargari… - … of Biochemical and …, 2024 - Wiley Online Library
Although cyclophosphamide (CP) has been approved as an anticancer drug, its toxic effect
on most organs, especially the testis, has been established. Piperine (PIP) is an alkaloid that …
on most organs, especially the testis, has been established. Piperine (PIP) is an alkaloid that …
Structure-activity relationship of anticancer drug candidate quinones
N Özenver, N Sönmez, MY BARAN… - Turkish Journal of …, 2024 - journals.tubitak.gov.tr
Breast cancer is one of the most prevalent cancer types worldwide. Chemotherapy is a
substantial approach in the management of breast cancer despite the occurrence of …
substantial approach in the management of breast cancer despite the occurrence of …
The Potential Protective Impact of Selenium on Cyclophosphamide Induced Hepatotoxicity and Nephrotoxicity in Adult Male Albino Rats
AR Hussieny Mahmoud… - Zagazig University …, 2024 - zumj.journals.ekb.eg
Background: Human exposure to cyclophosphamide (CP) is highly frequent because it is
widely used chemotherapeutic and immunosuppressive. CP has potential toxic effects on …
widely used chemotherapeutic and immunosuppressive. CP has potential toxic effects on …