Sjögren's syndrome is a chronic autoimmune disease characterized by ocular and oral
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …

Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in
recent decades: treatment decisions remain challenging in clinical practice, without a …

There is currently no approved treatment for primary Sjögren's syndrome, a disease that
primarily affects adult women. The difficulty in developing effective therapies is-in part …

In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …

Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Failure of regulatory T (Treg) cells to properly control immune responses leads invariably to
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …

CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …