This article provides a critical review of the different applications of ferrocene‐based
peptides/amides in biological as well as in non‐biological systems. Ferrocene‐based …

A series of biphenyl analogues of the new tuberculosis drug PA-824 was prepared, primarily
by coupling the known (6 S)-2-nitro-6, 7-dihydro-5 H-imidazo [2, 1-b][1, 3] oxazin-6-ol with …

The nitroimidazooxazine S-1 (PA-824) is a new class of bioreductive drug for tuberculosis. A
series of related bicyclic nitroheterocycles was synthesized, designed to have a wide range …

Tuberculosis (TB) has gone from being a forgotten disease to a modern and recrudescent
pathology from past decades. Some clinical problems and challenges associated with …

Recently described biphenyl analogues of the antituberculosis drug PA-824 displayed
improved potencies against M. tuberculosis but were poorly soluble. Heterobiaryl analogues …

Development of new drugs to treat tuberculosis (TB) faces even more constraints than the
development of therapeutic agents for other diseases. This is due, in part, to intrinsic …

Introduction The study aimed to develop and explore the efficiency of a surface-modified 4.0
G PAMAM dendrimer as a novel delivery system for the anti-tuberculosis (TB) drug …

Tuberculosis (TB) is a highly prevalent infectious disease that causes more than 1.5 million
deaths a year. More than 25% of TB deaths occur in Africa, and TB is South Africa's leading …

In this work we reported the synthesis and evaluation of Mycobacterium tuberculosis
activities in vitro of a series of twenty five ferrocenyl derivatives: ferrocenyl amides derived …

Analogues of clinical tuberculosis drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl] oxy}-6, 7-
dihydro-5 H-imidazo [2, 1-b][1, 3] oxazine (PA-824), in which the OCH2 linkage was …