Although heart failure (HF) is a clinical syndrome that becomes worse over time, certain
cases can be reversed with appropriate treatments. While coronary artery spasm (CAS) is …

Hyperlipidemia is a medical condition characterized by high levels of lipids in the blood. It is
often associated with an increased risk of cardiovascular diseases such as heart attacks and …

Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD)
as well as stroke. Endothelial metabolic disorder has been found to be activated and then …

Atherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and
inflammation in the intimal layer of arteries, and its main complications—myocardial …

Metabolic syndrome predisposes and contributes to the development and progression of
atherosclerosis. The minipig strain “Ossabaw” is characterized by a predisposition to …

Background: Tanshinone IIA (TIIA) is the major lipid-soluble active ingredient of the
traditional Chinese medicine Salvia miltiorrhiza, which slows down atherosclerosis (AS) …

Epidemiological data and interventional studies with hormone replacement therapy suggest
that women, at least until menopause, are at decreased cardiovascular risk compared to …

The past decade has witnessed an explosion in the tools, resources, and publicly available
data for human-based discovery implicating multiple new candidate pathways and potential …

Apolipoprotein E (APOE) was recognized as a key regulator of lipid metabolism, which
prompted the Apoe-knockout (Apoe−/−) mouse to be the most widely used atherosclerotic …

Mouse models have been used extensively to study human coronary artery disease (CAD)
or atherosclerosis and to test therapeutic targets. However, whether mouse and human …