Zebrafish as a model for obesity and diabetes

L Zang, LA Maddison, W Chen - Frontiers in cell and developmental …, 2018 - frontiersin.org
Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes
are increasing in parallel with the rates of obesity and the strong connection between these …

The use of zebrafish (Danio rerio) as biomedical models

T Teame, Z Zhang, C Ran, H Zhang, Y Yang… - Animal …, 2019 - academic.oup.com
Implications Because of its fully sequenced genome, easy genetic manipulation, high
fecundity, external fertilization and rapid development, and nearly transparent embryo …

Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease

P Gut, S Reischauer, DYR Stainier… - Physiological …, 2017 - journals.physiology.org
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Application of haematology parameters for health management in fish farms

H Chen, D Luo - Reviews in Aquaculture, 2023 - Wiley Online Library
Farmed fish are a promising source of high‐quality and sustainable protein. However, the
production of farmed fish products that meet food safety standards is one of the major public …

Immunotoxicities of microplastics and sertraline, alone and in combination, to a bivalve species: size-dependent interaction and potential toxication mechanism

W Shi, Y Han, S Sun, Y Tang, W Zhou, X Du… - Journal of hazardous …, 2020 - Elsevier
Although coexposure to pharmaceuticals and microplastics (MPs) may frequently occur, the
synergistic impact of MPs and antidepressants on marine species still remains poorly …

Zebrafish as model organisms for studying drug‐induced liver injury

ADB Vliegenthart, CS Tucker… - British journal of …, 2014 - Wiley Online Library
Drug‐induced liver injury (DILI) is a major challenge in clinical medicine and drug
development. New models are needed for predicting which potential therapeutic …

Intraperitoneal injection into adult zebrafish

MD Kinkel, SC Eames, LH Philipson… - JoVE (Journal of …, 2010 - jove.com
A convenient method for chemically treating zebrafish is to introduce the reagent into the
tank water, where it will be taken up by the fish. However, this method makes it difficult to …

Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish

M Michel, PS Page-McCaw… - Proceedings of the …, 2016 - National Acad Sciences
Leptin is the primary adipostatic factor in mammals. Produced largely by adipocytes in
proportion to total adipose mass, the hormone informs the brain regarding total energy …

Diazepam and fluoxetine decrease the stress response in zebrafish

MS Abreu, G Koakoski, D Ferreira, TA Oliveira… - PloS one, 2014 - journals.plos.org
The presence of pharmaceutical products in the aquatic environment has been reported in
several studies. However, the impact of these drugs on living organisms is still …

[HTML][HTML] Persistent impaired glucose metabolism in a zebrafish hyperglycemia model

KM Capiotti, RA Junior, LW Kist, MR Bogo… - … and Physiology Part B …, 2014 - Elsevier
Diabetes mellitus (DM) affects over 10% of the world's population. Hyperglycemia is the
main feature for the diagnosis of this disease. The zebrafish (Danio rerio) is an established …