It is often stated that type 1 diabetes results from a complex interplay between varying
degrees of genetic susceptibility and environmental factors. While agreeing with this …

Animal models have enormously contributed to the study of diabetes mellitus, a metabolic
disease with abnormal glucose homeostasis, due to some defect in the secretion or the …

Bacteria associated with the onset of type 1 diabetes in a rat model system were identified.
In two experiments, stool samples were collected at three time points after birth from bio …

Cannabidinoids are components of the Cannabis sativa (marijuana) plant that have been
shown capable of suppressing inflammation and various aspects of cell-mediated immunity …

During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides …

For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD)
and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The …

Immunodeficient NOD-scid mice bearing a targeted mutation in the IL2 receptor common
gamma chain (Il2rγnull) readily engraft with human stem cells. Here we analyzed human …

Background. Transplantation of human skin on immunodeficient mice that support
engraftment with functional human immune systems would be an invaluable tool for …

RNA-seq protocols that focus on transcript termini are well suited for applications in which
template quantity is limiting. Here we show that, when applied to end-sequencing data …

Much progress has been made in type 1 diabetes research. Biological replacement of islet
function has been achieved with pancreas transplantation and with islet transplantation. In …