There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

The discovery of the biological functions of the interleukin-23/-17 axis led to the identification
of IL-23 and IL-17 as important participants in the pathogenesis of several immune-mediated …

The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Psoriasis as a chronic inflammatory disease often requires effective long-term treatment; a
comprehensive systematic evaluation of efficacy and safety of systemic long-term treatments …

Introduction: Anti TNF-α agents have become a significant advance in the management of
ulcerative colitis, proving to induce, with rapid onset, clinical and endoscopic remission …

As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse
biological processes. Genome-wide association studies have revealed the link between …

ABSTRACT The cytokines interleukin (IL)-12 and interleukin (IL)-23 have been implicated
variously in the pathogenesis of psoriasis and psoriatic arthritis (PsA). By corollary, the IL …

Advances in the understanding of disease pathophysiology for inflammatory skin diseases
and in drug development have ushered in biologic therapies in dermatology. Biologic …

Objectives No gold standard exists to assess methodological quality of systematic reviews
(SRs). Although Assessing the Methodological Quality of Systematic Reviews (AMSTAR) is …

Objectives Despite their essential role in collecting and organizing published medical
literature, indexed search engines are unable to cover all relevant knowledge. Hence …