Tumor heterogeneity is a major problem in cancer treatment. Cancer stem cells (CSCs) are
a subpopulation of tumor masses that produce proliferating and quiescent cells. Under …

The failure in effective cancer treatment is thought to be attributed to a subpopulation of
tumor cells with stem cell-like properties. These cancer stem cells (CSCs) are intimately …

Purpose: To investigate whether CEACAM7 represents a novel therapeutic target for treating
pancreatic ductal adenocarcinoma (PDAC) and to generate CEACAM7-targeting CAR T …

Owing to increased awareness of the importance of mammogram and advances in surgical
technology, survival rate of patients with primary breast cancer has dramatically increased …

Triple-negative breast cancer (TNBC) has a high rate of metastasis, which is associated with
breast cancer stem-like cells (CSCs). Although Taxol (micelle formulation of paclitaxel) is the …

Simple Summary A major theory of cancer development is that cancer originates from a
specialised type of tumour cell called the cancer stem cell (CSC). Although CSCs comprise …

Simple Summary The extracellular matrix (ECM) has emerged as a critical part of the tumor
microenvironment. This glycoprotein-and proteoglycan-rich part of the tumor serves as a …

Background TP53 is one of the most frequently mutated genes among all cancer types, and
TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there …

Cancer cells utilise several mechanisms to increase their survival and progression as well
as their resistance to anticancer therapy: deregulation of growth regulatory pathways by …

Drug resistance is a major impediment in cancer therapy which strongly reduces the
efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical …