Biocatalysis: enzymatic synthesis for industrial applications

S Wu, R Snajdrova, JC Moore… - Angewandte Chemie …, 2021 - Wiley Online Library
Biocatalysis has found numerous applications in various fields as an alternative to chemical
catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for …

Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Power of biocatalysis for organic synthesis

CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Biocatalysis as key to sustainable industrial chemistry

AR Alcántara, P Domínguez de María… - …, 2022 - Wiley Online Library
The role and power of biocatalysis in sustainable chemistry has been continuously brought
forward step by step to its present outstanding position. The problem‐solving capabilities of …

Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions

RC Rodrigues, JJ Virgen-Ortíz, JCS Dos Santos… - Biotechnology …, 2019 - Elsevier
Lipases are the most widely used enzymes in biocatalysis, and the most utilized method for
enzyme immobilization is using hydrophobic supports at low ionic strength. This method …

Site-selective functionalization of hydroxyl groups in carbohydrate derivatives

V Dimakos, MS Taylor - Chemical reviews, 2018 - ACS Publications
Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are
reviewed. The construction of oligosaccharides of defined connectivity hinges on such …

Ionic liquids as tool to improve enzymatic organic synthesis

T Itoh - Chemical Reviews, 2017 - ACS Publications
Ionic liquids (ILs) have now been acknowledged as reaction media for biotransformations.
The first three examples were reported in this field in 2000, and since then, numerous …

Enzymes as green catalysts for precision macromolecular synthesis

S Shoda, H Uyama, J Kadokawa, S Kimura… - Chemical …, 2016 - ACS Publications
The present article comprehensively reviews the macromolecular synthesis using enzymes
as catalysts. Among the six main classes of enzymes, the three classes, oxidoreductases …

Engineering the third wave of biocatalysis

UT Bornscheuer, GW Huisman, RJ Kazlauskas, S Lutz… - Nature, 2012 - nature.com
Over the past ten years, scientific and technological advances have established biocatalysis
as a practical and environmentally friendly alternative to traditional metallo-and …

Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines

Y Yang, SL Shi, D Niu, P Liu, SL Buchwald - Science, 2015 - science.org
Catalytic assembly of enantiopure aliphatic amines from abundant and readily available
precursors has long been recognized as a paramount challenge in synthetic chemistry …