Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Arterial stiffness, a leading marker of risk in hypertension, can be measured at material or
structural levels, with the latter combining effects of the geometry and composition of the …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …

Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18,
20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases …

Hypertension prevalence increases with age. Age and high blood pressure are the two main
determinants of arterial stiffness. In elderly hypertensives, large arteries stiffen and systolic …

Safar et al Hypertension and Arterial Stiffness 797 amplification, though it actually refers to a
pressure waveform distortion rather than an amplification, the latter erroneously implying an …