The availability of highly active antiretroviral therapies (HAART) has not eliminated HIV-1
infection of the central nervous system (CNS) or the occurrence of HIV-associated …

HIV can invade cells of the central nervous system (CNS) and cause progressive combined
cognitive and motor impairment in infected individuals. The cellular basis and mechanisms …

Many patients infected with human immunodeficiency virus type-1 (HIV-1) suffer cognitive
impairment ranging from mild to severe (HIV dementia), which may result from neuronal …

Cell culture models have been extensively used for studies of blood–brain barrier (BBB)
function. However, several in vitro models fail to reproduce some, if not most, of the …

Blood-borne human immunodeficiency virus type 1 (HIV-1) crosses the blood-brain barrier
(BBB) to induce brain dysfunction. How HIV-1 crosses the BBB is unclear. Most work has …

We studied the temporal relationship between human immunodeficiency type 1 (HIV-1)
quasispecies in tissues and in peripheral blood mononuclear cells (PBMC) of infected …

The Tat protein of human immunodeficiency virus (HIV) type 1 is a transactivator of viral
gene expression that is required for virus replication and spread. Moreover, Tat is released …

Human immunodeficiency virus type 1 (HIV-1) infection of CD4+ lymphocytes and
macrophages involves interaction of the surface subunit of the envelope protein (gp120) …

Publisher Summary This chapter discusses various aspects of the central nervous system
complications directly associated with HIV-1—in particular, that of HIV dementia (HIVD) also …

Monocyte/macrophages and CD4 T‐cells are the primary hematopoietic targets of
productive HIV infection. In the brain, potential cellular targets for HIV infection include …