Human immunodeficiency virus type 1 (HIV-1) Tat transactivates viral genes and is released
by infected cells, acting as a soluble mediator. In endothelial cells (EC), it activates a …

Endothelial cells (EC) participate in inflammatory and immune reactions by producing and
responding to soluble mediators. Human immunodeficiency virus (HIV)-1 profoundly alters …

Chemokines have received increasing attention due to their inhibitory activities on human
immunodeficiency virus type-1 (HIV-1) and simian immunodeficiency virus (SIV) replication …

AIDS dementia complex affects 15-20% of HIV-infected adults and a greater percentage of
HIV-infected children. Whether or not an HIV-infected individual develops neurological …

A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites
are capable of entry into the central nervous system (CNS) and cause a variety of clinical …

Apart from in exceptional and rare circumstances when drugs may be inserted directly into
the CNS, it is often difficult to achieve therapeutically relevant dosages in the brain. This is …

Lentiviruses form a unique group of pathogens affecting a wide range of animals, including
man. The prefix" lenti"(It. lento= slow) characterizes most of the diseases associated with …

Human immunodeficiency virus (HIV)-I infection is associated with the development of
aggressive extranodal B-cell non-Hodgkin's lymphomas. Using microvascular endothelial …

—Human immunodeficiency virus (HIV)-1 within the CNS induces neuro-acquired
immunodeficiency syndrome and acts as a reservoir for reinfection of peripheral tissues. HIV …

One of the most devastating manifestations of human immunodeficiency virus (HIV) infection
in children is the development of neurologic dysfunction due to HIV encephalopathy. Early in …