Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Introduction Alzheimer's disease (AD) represents a global health crisis. Treatments are
needed to prevent, delay the onset, slow the progression, improve cognition, and reduce …

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in
medicinal plants. It has many health benefits due to its antioxidant properties. This study …

New methods for investigating human astrocytes are urgently needed, given their critical
role in the central nervous system. Here we show that CD49f is a novel marker for human …

The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …

Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

Glioblastoma multiforme (GBM) represents the most common and fatal form of primary
invasive brain tumors as it affects a great number of patients each year and has a median …

The concept of bioisosterism and the implementation of bioisosteric replacement is
fundamental to medicinal chemistry. The exploration of bioisosteres is often used to probe …

Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …