Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Antibiotic resistance has become an indispensably alarming menace to the global
community. The primary factors are overuse and abuse of antibiotics, lack of novel …

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly
common and are causing a global health crisis. Antibiotic resistance is encoded by several …

Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all
microorganisms. With few exceptions, they are chromosomally encoded and present a …

Quaternary ammonium compounds (QACs) have represented one of the most visible and
effective classes of disinfectants for nearly a century. With simple preparation, wide structural …

Multidrug resistance (MDR) refers to the capability of bacterial pathogens to withstand lethal
doses of structurally diverse drugs which are capable of eradicating non-resistant strains …

Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …

The qac genes of Staphylococcus species encode multidrug efflux pumps: membrane
proteins that export toxic molecules and thus increase tolerance to a variety of compounds …

Background: Naphthoquinones are natural pigments that are widely distributed in nature
and have important biological activities. Lawsone (2-hydroxy-1, 4-naphthoquinone) and its …

Gram-positive organisms are responsible for some of the most serious of human infections.
Resistance to front-line antimicrobial agents can complicate otherwise curative therapy …