Prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs): a long march towards synthesis of safer NSAIDs

S Sehajpal, DN Prasad… - Mini reviews in medicinal …, 2018 - ingentaconnect.com
As a therapeutic group, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most
widely used, prescribed and over the counter (OTC) medications for the treatment of …

[HTML][HTML] A perspective review on role of novel NSAID prodrugs in the management of acute inflammation

JP Peesa, PR Yalavarthi, A Rasheed… - Journal of Acute …, 2016 - Elsevier
Inflammation mediators, prostaglandins are causing inflammation, pain and pyrexia in the
body. Synthesis of these mediators can be effectively blocked by administering the non …

[HTML][HTML] Synthesis and investigation of anti-inflammatory activity of new thiourea derivatives of naproxen

N Nedeljković, V Dobričić, J Bošković, M Vesović… - Pharmaceuticals, 2023 - mdpi.com
The aim of the study was a synthesis and investigation of the dose-dependent anti-
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

AA Elhenawy, LM Al-Harbi, GO Moustafa… - Drug design …, 2019 - Taylor & Francis
Background and aim: Naproxen is a member of the Nonsteroidal anti-inflammatory drugs
(NSAIDs). This work aimed to synthesize a safe NSAID agent based on a peptide derivative …

Naproxen derivatives: synthesis, reactions, and biological applications

YA Ammar, MA Salem, EA Fayed, MH Helal… - Synthetic …, 2017 - Taylor & Francis
Full article: Naproxen derivatives: Synthesis, reactions, and biological applications Skip to Main
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Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by …

W Xu, J Yang, X Gu, W Su, F Pu, Z Xie, K Jin, W Su… - Drug Delivery, 2022 - Taylor & Francis
Ibuprofen (IBU) was a widely used NSAID (a type of nonsteroidal anti-inflammatory drug)
worldwide, and many drug deliveries had been reported to enhance bioavailability …

Molecular docking‐guided synthesis of NSAID–glucosamine bioconjugates and their evaluation as COX‐1/COX‐2 inhibitors with potentially reduced gastric toxicity

RA Jones Lipinski, Y Thillier… - Chemical biology & …, 2021 - Wiley Online Library
Non‐steroidal anti‐inflammatory drugs (NSAIDs) are a powerful class of inhibitors targeting
two isoforms of the family of cyclooxygenase enzymes (COX‐1 and COX‐2). While NSAIDs …

Benzotriazole-mediated syntheses of depsipeptides and oligoesters

I Avan, SR Tala, PJ Steel… - The Journal of Organic …, 2011 - ACS Publications
Reactions of O-Pg (α-hydroxyacyl) benzotriazoles with (a) unprotected α-hydroxycarboxylic
acids,(b) amino acids, and (c) amines afforded, respectively, chirally pure (a) oligoesters,(b) …

Exploring ibuprofen derivatives as α‐glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies

S Daud, OR Abid, A Sardar, S Abdullah… - Archiv der …, 2022 - Wiley Online Library
This study reports the synthesis of a series of ibuprofen derivatives, including
thiosemicarbazides 4a–f, 1, 3, 4‐oxadiazoles 5a–f, 1, 3, 4‐thiadiazoles 6a–f, 1, 2, 4‐triazoles …

Synthesis of (S)-naproxen-benzotriazole and its application as chiral derivatizing reagent for microwave-assisted synthesis and indirect high performance liquid …

R Bhushan, R Dubey - Journal of Chromatography a, 2011 - Elsevier
Abstract (S)-Naproxen-benzotriazole was synthesized by the reaction of (S)-naproxen with
1H-benzotriazole using coupling reagent dicyclohexyl carbodiimide and 4-dimethylamino …