Pulmonary diseases represent four out of ten most common causes for worldwide mortality.
Thus, pulmonary infections with subsequent inflammatory responses represent a major …

Within the pulmonary acini ventilation and blood perfusion are brought together on a huge
surface area separated by a very thin blood-gas barrier of tissue components to allow …

Intravital microscopy (IVM) is a unique imaging method providing insights in cellular
functions and interactions in real-time, without the need for tissue extraction from the body …

Emphysema is a chronic respiratory disease characterized by interalveolar septa destruction
and enlarged air sacs. How the inhalation dosimetry in the pulmonary acini varies in the time …

Physics-based multi-scale in silico models offer an excellent opportunity to study the effects
of heterogeneous tissue damage on airflow and pressure distributions in COVID-19-afflicted …

Methods Two groups of pigs were sedated and ventilated using lung-protective volume-
controlled mode at 8 mL/kg, positive end-expiratory pressure (PEEP) 5 cmH 2 O, with …

Mechanical ventilation triggers the manifestation of lung injury and pre-injured lungs are
more susceptible. Ventilation-induced abnormalities of alveolar surfactant are involved in …

Since the 19th century, underwater explosions have posed a significant threat to service
members. While there have been attempts to establish injury criteria for the most vulnerable …

Mesenchymal stem cells (MSCs) have been widely used to treat various inflammatory and
immune-related diseases in preclinical and clinical settings. Intravital microscopy (IVM) is …

Intravital imaging of leukocyte-endothelial interactions offers valuable insights into immune-
mediated disease in live animals. The study of acute lung injury (ALI)/acute respiratory …