[HTML][HTML] Seeing is believing: Exploiting advances in structural biology to understand and engineer plant immunity

MA Outram, M Figueroa, J Sperschneider… - Current Opinion in Plant …, 2022 - Elsevier
Filamentous plant pathogens cause disease in numerous economically important crops.
These pathogens secrete virulence proteins, termed effectors, that modulate host cellular …

Advancement in the breeding, biotechnological and genomic tools towards development of durable genetic resistance against the rice blast disease

PK Sahu, R Sao, DK Choudhary, A Thada, V Kumar… - Plants, 2022 - mdpi.com
Rice production needs to be sustained in the coming decades, as the changeable climatic
conditions are becoming more conducive to disease outbreaks. The majority of rice …

A designer rice NLR immune receptor confers resistance to the rice blast fungus carrying noncorresponding avirulence effectors

Y Liu, X Zhang, G Yuan, D Wang… - Proceedings of the …, 2021 - National Acad Sciences
Plant nucleotide-binding and leucine-rich repeat (NLR) receptors recognize avirulence
effectors directly through their integrated domains (IDs) or indirectly via the effector-targeted …

Computational Structural Genomics Unravels Common Folds and Novel Families in the Secretome of Fungal Phytopathogen Magnaporthe oryzae

K Seong, KV Krasileva - Molecular Plant-Microbe Interactions, 2021 - Am Phytopath Society
Structural biology has the potential to illuminate the evolution of pathogen effectors and their
commonalities that cannot be readily detected at the primary sequence level. Recent …

Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors

Y Cao, F Kümmel, E Logemann… - Proceedings of the …, 2023 - National Acad Sciences
In plants, host–pathogen coevolution often manifests in reciprocal, adaptive genetic
changes through variations in host nucleotide-binding leucine-rich repeat immune receptors …

A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice

JC De la Concepcion, K Fujisaki… - Proceedings of the …, 2022 - National Acad Sciences
Exocytosis plays an important role in plant–microbe interactions, in both pathogenesis and
symbiosis. Exo70 proteins are integral components of the exocyst, an octameric complex …

Show me your ID: NLR immune receptors with integrated domains in plants

C Marchal, VA Michalopoulou, Z Zou… - Essays in …, 2022 - portlandpress.com
Nucleotide-binding and leucine-rich repeat receptors (NLRs) are intracellular plant immune
receptors that recognize pathogen effectors secreted into the plant cell. Canonical NLRs …

Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector

R Zdrzałek, Y Xi, T Langner, AR Bentham… - Proceedings of the …, 2024 - pnas.org
Bioengineering of plant immune receptors has emerged as a key strategy for generating
novel disease resistance traits to counteract the expanding threat of plant pathogens to …

The E3 ubiquitin ligase OsRGLG5 targeted by the Magnaporthe oryzae effector AvrPi9 confers basal resistance against rice blast

Z Liu, J Qiu, Z Shen, C Wang, N Jiang, H Shi… - Plant Communications, 2023 - cell.com
Rice blast, caused by Magnaporthe oryzae, is one of the most devastating diseases of rice.
During infection, M. oryzae secretes effectors to facilitate blast development. Among these …

A single amino acid polymorphism in a conserved effector of the multihost blast fungus pathogen expands host-target binding spectrum

AR Bentham, Y Petit-Houdenot, J Win, I Chuma… - PLoS …, 2021 - journals.plos.org
Accelerated gene evolution is a hallmark of pathogen adaptation and specialization
following host-jumps. However, the molecular processes associated with adaptive evolution …