Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …

Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA);
however, the mechanism by which DNA damage drives OA is unclear. Previous research …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Osteoarthritis (OA) is one of the most common musculoskeletal disorders worldwide.
Oxidative stress initiated by excessive free radicals such as reactive oxygen species (ROS) …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …

Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Anti-oxidative agents hold great potential in osteoarthritis (OA) therapy. However, most
radical scavengers have poor biocompatibility and potential cytotoxicity, which limit their …

Cell senescence is a chronic process associated with age-related degenerative diseases
such as osteoarthritis (OA). Senescent cells (SnCs) accumulate in the articular cartilage and …