Abstract Purpose of Review Myocardial metabolism is intricately linked to cardiac function.
Perturbations of cardiac energy metabolism result in an energy-starved heart and the …

Type 2 diabetes mellitus (T2DM) is one of the most common diseases of endocrine and
metabolic disorders, whose mechanism is still largely unknown. Fortunately, various “omics” …

Diabetic cardiomyopathy is associated with increased risk of heart failure in type 1 diabetic
patients. Mitochondrial dysfunction is suggested as an underlying contributor to diabetic …

Proteomics is very much a technology-driven field. The ambition is to identify, quantify and to
assess the state of posttranslational modification and interaction partners for every protein in …

Hypertension plays a major role in the development and progression of micro-and
macrovascular disease. Moreover, increased blood pressure often coexists with additional …

The heart is an omnivore organ that requires constant energy production to match its
functional demands. In the adult heart, adenosine‐5′‐triphosphate (ATP) production …

This article reviews recent evidence, much of which has been generated by my group's
research programme, which has identified for the first time a previously unknown copper …

As∼ 80% of diabetic patients die from heart failure, an understanding of diabetic
cardiomyopathy is crucial. Mitochondria occupy 35–40% of the mammalian cardiomyocyte …

Mitochondrial dysfunction is a contributor to diabetic cardiomyopathy. Previously, we
observed proteomic decrements within the inner mitochondrial membrane (IMM) and matrix …

Oxidative stress and mitochondrial dysfunction have been identified by many workers as key
pathogenic mechanisms in ageing-related metabolic, cardiovascular and …