[HTML][HTML] Lung neuroendocrine neoplasms: recent progress and persistent challenges
N Rekhtman - Modern Pathology, 2022 - Elsevier
This review summarizes key recent developments relevant to the pathologic diagnosis of
lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma (SCLC) …
lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma (SCLC) …
[HTML][HTML] Morphologic and molecular classification of lung neuroendocrine neoplasms
J Metovic, M Barella, F Bianchi, P Hofman, V Hofman… - Virchows Archiv, 2021 - Springer
Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs)
composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) …
composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) …
[HTML][HTML] Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
[HTML][HTML] POU2F3 in SCLC: clinicopathologic and genomic analysis with a focus on its diagnostic utility in neuroendocrine-low SCLC
MK Baine, CA Febres-Aldana, JC Chang… - Journal of Thoracic …, 2022 - Elsevier
Introduction POU2F3 is a recent marker of a small cell lung carcinoma (SCLC) subtype
related to chemosensory tuft cells (SCLC-P). The characteristics of SCLC-P have not been …
related to chemosensory tuft cells (SCLC-P). The characteristics of SCLC-P have not been …
[HTML][HTML] Neuroendocrine neoplasm update: toward universal nomenclature
Neuroendocrine neoplasia is described in almost every tissue, either in the pure endocrine
organs, the nerve structures or in the so-called diffuse neuroendocrine system. The current …
organs, the nerve structures or in the so-called diffuse neuroendocrine system. The current …
Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications
The remarkable genetic heterogeneity of multiple myeloma poses a substantial challenge
for proper prognostication and clinical management of patients. Here, we introduce MM …
for proper prognostication and clinical management of patients. Here, we introduce MM …
[HTML][HTML] Clinical-pathologic challenges in the classification of pulmonary neuroendocrine neoplasms and targets on the horizon for future clinical practice
JL Derks, N Rijnsburger, BCM Hermans… - Journal of Thoracic …, 2021 - Elsevier
Diagnosing a pulmonary neuroendocrine neoplasm (NEN) may be difficult, challenging
clinical decision making. In this review key clinical and pathological issues and informative …
clinical decision making. In this review key clinical and pathological issues and informative …
ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications
F Jin, Z Yang, J Shao, J Tao, C Reißfelder… - Trends in Molecular …, 2023 - cell.com
Mutations in the AT-interacting domain-rich protein 1A (ARID1A) gene, a critical component
of the switch/sucrose nonfermentable (SWI/SNF) complex, are frequently found in most …
of the switch/sucrose nonfermentable (SWI/SNF) complex, are frequently found in most …
Neuroendocrinology of the lung revealed by single-cell RNA sequencing
CS Kuo, S Darmanis, AD de Arce, Y Liu, N Almanzar… - Elife, 2022 - elifesciences.org
Pulmonary neuroendocrine cells (PNECs) are sensory epithelial cells that transmit airway
status to the brain via sensory neurons and locally via calcitonin gene-related peptide …
status to the brain via sensory neurons and locally via calcitonin gene-related peptide …
[HTML][HTML] Molecular pathology of well-differentiated pulmonary and thymic neuroendocrine tumors: what do pathologists need to know?
Thoracic (pulmonary and thymic) neuroendocrine tumors are well-differentiated epithelial
neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors …
neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors …