The degradation of eukaryotic mRNAs plays important roles in the modulation of gene
expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years …

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …

Messenger RNA (mRNA) degradation in eukaryotic cells is a regulated process that can
determine the level of expression of a gene. In particular, the existence of highly unstable …

Based on the above mechanisms of mRNA degradation, an integrated model of mRNA
turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be …

MicroRNAs (miRNAs) are typically generated as∼ 22-nucleotide double-stranded RNAs via
the processing of precursor hairpins by the ribonuclease III enzyme Dicer, after which they …

We report that newly synthesized mRNA poly (A) tails are matured to precise lengths by the
Pab1p-dependent poly (A) nuclease (PAN) ofSaccharomyces cerevisiae. These results …

Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and are
essential for fertility in diverse organisms. An interesting feature of piRNAs is that, while …

3′-Exonucleolytic removal of the poly (A) tail is the first and often rate-limiting step in the
decay of many eucaryotic mRNAs. In a cytoplasmic extract from HeLa cells, the poly (A) tail …

Eukaryotic rRNAs (with the exception of 5S rRNA) are synthesized from a contiguous pre-
rRNA precursor by a complex series of processing reactions. Final maturation of yeast 5.8 S …

As part of our genetic analysis of mRNA decay in Escherichia coli K-12, we examined the
effect of the pcnB gene [encoding poly (A) polymerase I] on message stability. Eliminating …