Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …

Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …

Hereditary non-polyposis colorectal cancer (HNPCC) was previously synonymous with
Lynch syndrome; however, identification of the role of germline mutations in the DNA …

Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6,
and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of …

Background Standard screening of endometrial cancer (EC) for Lynch syndrome (LS) is
gaining traction; however, the prognostic impact of an underlying hereditary etiology is …

Background Histopathological diagnosis of diffuse gliomas is subject to interobserver
variation and correlates modestly with major prognostic and predictive molecular …

Identification of individuals with inherited predispositions to cancer, including Lynch
syndrome, can help prevent cancer and cancer-related death by allowing for the uptake of …

Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …

Background Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA
mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States …