Abstract The Pacific Northwest outbreak of cryptococcosis, caused by a near-clonal lineage
of the fungal pathogen Cryptococcus gattii, represents the most significant cluster of life …

The phylum Basidiomycota includes filamentous fungi and yeast species with different
ecological and genomic characteristics. Transposable elements (TEs) are abundant …

The pathogenic fungus Cryptococcus neoformans generally initiates infection in mammalian
lung tissue and subsequently disseminates to the brain. We performed serial analysis of …

Pathogenic fungi represent an increasing infectious disease threat to humans, especially
with an increasing challenge of antifungal drug resistance. Over the decades, numerous …

Iron availability is a key regulator of virulence factor elaboration in Cryptococcus
neoformans, the causative agent of fungal meningoencephalitis in HIV/AIDS patients. In …

Background The adaptation of pathogenic fungi to the host environment via large-scale
genomic changes is a poorly characterized phenomenon. Cryptococcus neoformans is the …

Cryptococcus gattii, an emerging fungal pathogen of humans and animals, is found on a
variety of trees in tropical and temperate regions. The ecological niche and virulence of this …

Background Genome variability can have a profound influence on the virulence of
pathogenic microbes. The availability of genome sequences for two strains of the AIDS …

The battle for iron between invading microorganisms and mammalian hosts is a pivotal
determinant of the outcome of infection. The pathogenic fungus, Cryptococcus neoformans …

Cryptococcus gattii is an emerging fungal pathogen on the west coast of Canada and the
United States that causes a potentially fatal infection in otherwise healthy individuals. In …