Abstract Sphingosine kinase (SK) 1 and 2 are lipid kinases that catalyse the formation of
sphingosine 1-phosphate (S1P), a potent signalling molecule with a wide array of cellular …

Sphingosine kinase 1 (SPHK1) regulates cell proliferation and survival by converting
sphingosine to the signaling mediator sphingosine 1-phosphate (S1P). SPHK1 is widely …

Previous studies have identified sphingosine kinase 1 (SphK1) as a potential drug target for
treatment of acute myeloid leukemia (AML). In the current study, we investigated the …

Osteosarcoma (OS) is one of the most common and aggressive malignancies in children
and adolescents worldwide. Sphingosine kinase 1 (SphK1) has recently been reported to …

The airway epithelium (AE) is the main protective barrier between the host and external
environmental factors causing asthma. Allergens or pathogens induce AE dysfunction …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer type,
with an annual incidence of approximately half a million people worldwide. It has a high …

Adrenocortical carcinoma (ACC) is a rare endocrine tumor with a very poor prognosis.
Sphingosine kinase 1 (SphK1), an oncogenic kinase, has previously been found to be …

Background The epidermal growth factor receptor (EGFR) is an important regulator of cell
growth and survival, and is highly variable in tumor cells. The most prevalent variation of the …

Abstract Sphingosine kinase 1 (SphK1) is overexpressed in skin squamous cell carcinoma
(SCC). It has emerged as a novel therapeutic oncotarget. The current study identified a …

Es konnte gezeigt werden, dass Kopf-Hals-Plattenepithelkarzinomzellen (HNSCC) zu
gesteigerter Migration von mesenchymalen Fettgewebsstammzellen (ASC) in vitro führen …