Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our
understanding of cardiac contraction. Although troponins are expressed in both skeletal and …

New biomarkers are being evaluated for their ability to advance the management of patients
with heart failure. Despite a large pool of interesting candidate biomarkers, besides …

Serum biomarkers are an important tool in the baseline risk assessment and diagnosis of
cardiovascular disease in cancer patients receiving cardiotoxic cancer treatments. Increases …

Background High-sensitivity cardiac troponin assays permit use of lower thresholds for the
diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown …

Aims Contemporary adjuvant treatment for early breast cancer is associated with improved
survival but at the cost of increased risk of cardiotoxicity and cardiac dysfunction. We tested …

Serological assessment of cardiac troponins (cTn) is the gold standard to assess myocardial
injury in clinical practice. A greater magnitude of acutely or chronically elevated cTn …

Myocardial infarction (MI) can be recognised by clinical features, including
electrocardiographic (ECG) findings, elevated values of biochemical markers (biomarkers) …

Background Suspected acute coronary syndrome is the commonest reason for emergency
admission to hospital and is a large burden on health-care resources. Strategies to identify …

Background: High-sensitivity cardiac troponin assays enable myocardial infarction to be
ruled out earlier, but the safety and efficacy of this approach is uncertain. We investigated …

Objective To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin
I assay and sex specific diagnostic thresholds in men and women with suspected acute …