The extracellular matrix (ECM) provides the environment for many cells types within the
body and, in addition to the well recognised role as a structural support, influences many …

Healthy mature arteries are usually extremely quiescent tissues with cell proliferation rates
much below 1%/day and with extracellular matrix constituents exhibiting half-lives of years to …

Complementary advances in medical imaging, vascular biology and biomechanics promise
to enable computational modelling of abdominal aortic aneurysms to play increasingly …

Airway epithelium repair after infection consists of wound repair, re-synthesis of the
extracellular matrix (ECM), and tight junction proteins. In humans, EPs® 7630 obtained from …

Elastin and collagen are the main components of the lung connective tissue network, and
together provide the lung with elasticity and tensile strength. In pulmonary pathology, elastin …

A primary deficiency in predicting the progression and rupture-risk of abdominal aortic
aneurysms (AAAs) is an inability to assign patient-specific, heterogeneous biomechanical …

Background The formation of discrete elastin bands at the tips of secondary alveolar septa is
important for normal alveolar development, but the mechanisms regulating the lung …

Injury to rat blood vessels in vivo was found to release intracellular pools of protein D-
aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where …

It is generally accepted that, once laid down in the extracellular matrix, elastin turns over
only very slowly if at all. However, much of the evidence for minimal turnover of elastin …

Disclosed herein are compositions and methods for the treatment of one or more
progressive lung diseases, which may include, but are not limited to, chronic obstructive …