Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management

L Ramiro, A Simats… - Therapeutic …, 2018 - journals.sagepub.com
Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide.
Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to …

In vitro oxygen glucose deprivation model of ischemic stroke: a proteomics-driven systems biological perspective

M Babu, N Singh, A Datta - Molecular Neurobiology, 2022 - Springer
Oxygen glucose deprivation (OGD) of brain cells is the commonest in vitro model of ischemic
stroke that is used extensively for basic and preclinical stroke research. Protein mass …

Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases

B Gril, AN Paranjape, S Woditschka, E Hua… - Nature …, 2018 - nature.com
Brain metastases are devastating complications of cancer. The blood–brain barrier (BBB),
which protects the normal brain, morphs into an inadequately characterized blood–tumor …

The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the …

L Deng, BL Spencer, JA Holmes, R Mu, S Rego… - PLoS …, 2019 - journals.plos.org
Streptococcus agalactiae (Group B Streptococcus, GBS) normally colonizes healthy adults
but can cause invasive disease, such as meningitis, in the newborn. To gain access to the …

Lucifer yellow-a robust paracellular permeability marker in a cell model of the human blood-brain barrier

W Zhao, L Han, Y Bae, DS Manickam - JoVE (Journal of Visualized …, 2019 - jove.com
The blood-brain barrier BBB consists of endothelial cells that form a barrier between the
systemic circulation and the brain to prevent the exchange of non-essential ions and toxic …

sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy

A da Silva‐Candal, A Custodia… - Annals of Clinical …, 2022 - Wiley Online Library
Objective Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology
associated with the appearance and worsening of vascular pathologies. The aim is to …

Characterization of a two-component system transcriptional regulator, LtdR, that impacts group B streptococcal colonization and disease

L Deng, R Mu, TA Weston, BL Spencer… - Infection and …, 2018 - Am Soc Microbiol
Streptococcus agalactiae (group B Streptococcus [GBS]) is often a commensal bacterium
that colonizes healthy adults asymptomatically and is a frequent inhabitant of the vaginal …

Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis

A Medina-Dols, G Cañellas, T Capó, M Solé… - Cell death …, 2024 - nature.com
Through GWAS studies we identified PATJ associated with functional outcome after
ischemic stroke (IS). The aim of this study was to determine PATJ role in brain endothelial …

Grapevine–downy mildew rendezvous: Proteome analysis of the first hours of an incompatible interaction

R B. Santos, R Nascimento, A V. Coelho, A Figueiredo - Plants, 2020 - mdpi.com
Grapevine is one of the most relevant crops in the world being used for economically
important products such as wine. However, relevant grapevine cultivars are heavily affected …

Reprogramming of lipid metabolism as a new driving force behind tauroursodeoxycholic acid-induced neural stem cell proliferation

MB Fernandes, M Costa, MF Ribeiro… - Frontiers in Cell and …, 2020 - frontiersin.org
Recent evidence suggests that neural stem cell (NSC) fate is highly dependent on
mitochondrial bioenergetics. Tauroursodeoxycholic acid (TUDCA), an endogenous …