The ubiquitous purine nucleoside phosphorylases (PNPs) play a key role in the purine
salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function …

The centrosome is an indispensable component of the cell-cycle machinery of eukaryotic
cells, and the perturbation of core centrosomal or centrosome-associated proteins is linked …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-
targets based on their ligand binding sites. Concurrent developments in systems biology …

Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0
mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction …

In the aging population, lower urinary tract (LUT) dysfunction is common and often leads to
storage and voiding difficulties classified into overlapping symptom syndromes. Despite …

Backgrounds Hypouricemia was reported as a risk factor for exercise-induced acute renal
injury (EIAKI) and urinary stones. However, the prevalence of kidney diseases among …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by
inflammation of multiple organ systems and dysregulated interferon responses. SLE is both …

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The lower urinary tract (LUT), including the bladder, urethra and external striated muscle,
becomes dysfunctional with age; consequently, many older individuals suffer from lower …