Epstein–Barr virus: more than 50 years old and still providing surprises
It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was
discovered. EBV has subsequently been found to be associated with a diverse range of …
discovered. EBV has subsequently been found to be associated with a diverse range of …
Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment
C Steidl, JM Connors, RD Gascoyne - Journal of Clinical Oncology, 2011 - ascopubs.org
Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …
young people in the Western world. Most patients can be cured with modern treatment …
Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma
Signaling between programmed cell death protein 1 (PD-1) and the PD-1 ligands (PD-L1,
PD-L2) is essential for malignant Hodgkin Reed-Sternberg (HRS) cells to evade antitumor …
PD-L2) is essential for malignant Hodgkin Reed-Sternberg (HRS) cells to evade antitumor …
Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells
J Reichel, A Chadburn, PG Rubinstein… - Blood, The Journal …, 2015 - ashpublications.org
Classical Hodgkin lymphoma (cHL) is characterized by sparsely distributed Hodgkin and
Reed-Sternberg (HRS) cells amid reactive host background, complicating the acquisition of …
Reed-Sternberg (HRS) cells amid reactive host background, complicating the acquisition of …
Familial predisposition and genetic risk factors for lymphoma
Our understanding of familial predisposition to lymphoma (collectively defined as non-
Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia …
Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia …
Classical Hodgkin Lymphoma with Reduced β2M/MHC Class I Expression Is Associated with Inferior Outcome Independent of 9p24.1 Status
MGM Roemer, RH Advani, RA Redd, GS Pinkus… - Cancer immunology …, 2016 - AACR
In classical Hodgkin lymphoma (cHL), malignant Hodgkin Reed–Sternberg (HRS) cells
evade antitumor immunity by multiple mechanisms, including perturbed antigen …
evade antitumor immunity by multiple mechanisms, including perturbed antigen …
Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell–rich and exhausted T-effector microenvironment
FZ Cader, RCJ Schackmann, X Hu… - Blood, The Journal …, 2018 - ashpublications.org
In classical Hodgkin lymphoma (cHL), the host antitumor immune response is ineffective.
Hodgkin Reed-Sternberg (HRS) cells have multifaceted mechanisms to evade the immune …
Hodgkin Reed-Sternberg (HRS) cells have multifaceted mechanisms to evade the immune …
[HTML][HTML] Risk factors for Epstein Barr virus-associated cancers: a systematic review, critical appraisal, and mapping of the epidemiological evidence
D Bakkalci, Y Jia, JR Winter, JEA Lewis… - Journal of global …, 2020 - ncbi.nlm.nih.gov
Background Epstein Barr Virus (EBV) infects 90%-95% of all adults globally and causes~
1% of all cancers. Differing proportions of Burkitt's lymphoma (BL), gastric carcinoma (GC) …
1% of all cancers. Differing proportions of Burkitt's lymphoma (BL), gastric carcinoma (GC) …
Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8+ T-cell function in Hodgkin …
MK Gandhi, E Lambley, J Duraiswamy, U Dua, C Smith… - Blood, 2006 - ashpublications.org
In Hodgkin lymphoma (HL), the malignant Hodgkin Reed-Sternberg (HRS) cells constitute
only 0.5% of 10% of the diseased tissue. The surrounding cellular infiltrate is enriched with T …
only 0.5% of 10% of the diseased tissue. The surrounding cellular infiltrate is enriched with T …