Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Abstract l‐glutamate is the predominant excitatory neurotransmitter in the CNS and has a
central role in a variety of brain functions. The termination of glutamate neurotransmission by …

Amyotrophic lateral sclerosis (ALS) has a multitude of factors implicated in its etiology. The
complex neuro-etiology and the restrictive nature of the blood–brain barrier (BBB) have …

Currently, oxidative stress (OS) has become a major interest in point of basic science and
clinical research. The imbalance between generations and clearances of oxidants leads to …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the first
and second motoneurons (MNs), associated with muscle weakness, paralysis and finally …

It is well established that motor neurons are highly vulnerable to glutamate induced
excitotoxicity. The selective vulnerability of these neurons has been attributed to AMPA …

The rise in intracellular Ca2+ mediated by AMPA subtype of glutamate receptors has been
implicated in the pathogenesis of motor neuron disease, but the exact route of Ca2+ entry …

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl) propanoic acid (AMPA) receptors comprise
an important class of ionotropic glutamate receptors activated by glutamate in the central …

The neuroblastoma–spinal motor neuron fusion cell line, NSC-34, in its differentiated form,
NSC-34D, permits examining the effects of riluzole, a proven treatment for amyotrophic …

This Perspective provides a background to the pathogenesis of neurodegenerative disease
and specifically amyotrophic lateral sclerosis (ALS) and gives an overview of the many …