The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …

Abstract Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases
which are best known for their ability to proteolyse extracellular matrix proteins throughout …

The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes
were originally described as cleaving extracellular matrix (ECM) substrates with a …

The transcription factor FOSL1 plays an important role in cell differentiation and
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …

The innate immune system is critical in recognizing bacterial and viral infections to evoke a
proper immune response. Certain members of the intracellular nucleotide‐binding and …

Matrix metalloproteinases (MMPs) have been shown to play significant roles in a number of
physiological as well as pathological processes. Best known to proteolyse components of …

Matrix metalloproteinases (MMPs) degrade collagen and mediate tissue remodeling. The
novel cytokine IL-17 is expressed during various inflammatory conditions and modulates …