[HTML][HTML] Microglia centered pathogenesis in ALS: insights in cell interconnectivity
D Brites, AR Vaz - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …
Excitotoxicity in ALS: overstimulation, or overreaction?
AE King, A Woodhouse, MTK Kirkcaldie… - Experimental neurology, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …
[HTML][HTML] AAV targeting of glial cell types in the central and peripheral nervous system and relevance to human gene therapy
Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …
system (PNS), where they have important functions. These cell types are also involved in …
Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha
Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease affecting both upper and lower motor neurons. While it is …
neurodegenerative disease affecting both upper and lower motor neurons. While it is …
[HTML][HTML] The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
S Lee, S Kim, HY Kang, HR Lim, Y Kwon, M Jo… - Journal of …, 2020 - Springer
Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …
[HTML][HTML] Phagocytic roles of glial cells in healthy and diseased brains
YJ Jung, WS Chung - Biomolecules & Therapeutics, 2018 - ncbi.nlm.nih.gov
Glial cells are receiving much attention since they have been recognized as important
regulators of many aspects of brain function and disease. Recent evidence has revealed …
regulators of many aspects of brain function and disease. Recent evidence has revealed …
Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production
JV McGivern, TN Patitucci, JA Nord, MEA Barabas… - Glia, 2013 - Wiley Online Library
Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival
motor neuron 1 (SMN1) gene that leads to loss of motor neurons in the spinal cord. Although …
motor neuron 1 (SMN1) gene that leads to loss of motor neurons in the spinal cord. Although …
Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease
I Smaga, D Fierro, J Mesa, M Filip… - … & Biobehavioral Reviews, 2020 - Elsevier
Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …
[HTML][HTML] Recovery of depleted miR-146a in ALS cortical astrocytes reverts cell aberrancies and prevents paracrine pathogenicity on microglia and motor neurons
M Barbosa, C Gomes, C Sequeira… - Frontiers in Cell and …, 2021 - frontiersin.org
Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular
expression pattern and release toxic factors that contribute to neurodegeneration and …
expression pattern and release toxic factors that contribute to neurodegeneration and …
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis
Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration
of motoneurons (MN) and their axons, but is also influenced by neighboring cells such as …
of motoneurons (MN) and their axons, but is also influenced by neighboring cells such as …