[HTML][HTML] Microglia centered pathogenesis in ALS: insights in cell interconnectivity

D Brites, AR Vaz - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Excitotoxicity in ALS: overstimulation, or overreaction?

AE King, A Woodhouse, MTK Kirkcaldie… - Experimental neurology, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

[HTML][HTML] AAV targeting of glial cell types in the central and peripheral nervous system and relevance to human gene therapy

SJ O'Carroll, WH Cook, D Young - Frontiers in Molecular …, 2021 - frontiersin.org
Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …

Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha

A Kia, K McAvoy, K Krishnamurthy, D Trotti, P Pasinelli - Glia, 2018 - Wiley Online Library
Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease affecting both upper and lower motor neurons. While it is …

[HTML][HTML] The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

S Lee, S Kim, HY Kang, HR Lim, Y Kwon, M Jo… - Journal of …, 2020 - Springer
Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

[HTML][HTML] Phagocytic roles of glial cells in healthy and diseased brains

YJ Jung, WS Chung - Biomolecules & Therapeutics, 2018 - ncbi.nlm.nih.gov
Glial cells are receiving much attention since they have been recognized as important
regulators of many aspects of brain function and disease. Recent evidence has revealed …

Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production

JV McGivern, TN Patitucci, JA Nord, MEA Barabas… - Glia, 2013 - Wiley Online Library
Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival
motor neuron 1 (SMN1) gene that leads to loss of motor neurons in the spinal cord. Although …

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

I Smaga, D Fierro, J Mesa, M Filip… - … & Biobehavioral Reviews, 2020 - Elsevier
Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …

[HTML][HTML] Recovery of depleted miR-146a in ALS cortical astrocytes reverts cell aberrancies and prevents paracrine pathogenicity on microglia and motor neurons

M Barbosa, C Gomes, C Sequeira… - Frontiers in Cell and …, 2021 - frontiersin.org
Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular
expression pattern and release toxic factors that contribute to neurodegeneration and …

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis

L Tönges, R Günther, M Suhr, J Jansen, A Balck… - Glia, 2014 - Wiley Online Library
Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration
of motoneurons (MN) and their axons, but is also influenced by neighboring cells such as …