Type 1 diabetes: etiology, immunology, and therapeutic strategies

TL Van Belle, KT Coppieters… - Physiological …, 2011 - journals.physiology.org
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

EN Gurzov, DL Eizirik - Trends in cell biology, 2011 - cell.com
Diabetes is a metabolic disease affecting nearly 300 million individuals worldwide. Both
types of diabetes (1 and 2) are characterized by loss of functional pancreatic β-cell mass …

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of …

SJ Richardson, P Leete, AJ Bone, AK Foulis… - Diabetologia, 2013 - Springer
Aims/hypothesis Immunohistochemical staining reveals that the enteroviral capsid protein
VP1 is present at higher frequency in the insulin-containing islets of patients with recent …

Infectious entry pathway of enterovirus B species

V Marjomäki, P Turkki, M Huttunen - Viruses, 2015 - mdpi.com
Enterovirus B species (EV-B) are responsible for a vast number of mild and serious acute
infections. They are also suspected of remaining in the body, where they cause persistent …

Enteroviruses and type 1 diabetes: towards a better understanding of the relationship

H Jaïdane, P Sauter, F Sane, A Goffard… - Reviews in medical …, 2010 - Wiley Online Library
Environmental factors, especially viruses, are involved in the initiation or the acceleration of
type 1 diabetes (T1D) pathogenesis. Epidemiological data strongly suggest that …

Extracellular albumin and endosomal ions prime enterovirus particles for uncoating that can be prevented by fatty acid saturation

V Ruokolainen, A Domanska, M Laajala… - Journal of …, 2019 - Am Soc Microbiol
There is limited information about the molecular triggers leading to the uncoating of
enteroviruses under physiological conditions. Using real-time spectroscopy and sucrose …

Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models

H Jaïdane, F Sané, J Gharbi, M Aouni… - Diabetes/metabolism …, 2009 - Wiley Online Library
The role of enteroviruses, in particular type B coxsackieviruses (CV‐B), in type 1 diabetes
(T1D) pathogenesis is supported by epidemiological, clinical and experimental …

Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues

Y Jin, H Gao, H Chen, J Wang, M Chen, G Li, L Wang… - Cancer letters, 2013 - Elsevier
Increasing evidence suggests that a link exists between hepatitis B virus (HBV) serum
markers and pancreatic cancer (PC). In this study, HBsAg and HBcAg were expressed in …

Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ

M Laajala, M Zwaagstra, M Martikainen… - Microbiology …, 2023 - Am Soc Microbiol
Enteroviruses are one of the most abundant viruses causing mild to serious acute infections
in humans and also contributing to chronic diseases like type 1 diabetes. Presently, there …

Diabetic ketoacidosis: an overlooked child killer in sub‐S aharan A frica?

AN Murunga, PMO Owira - Tropical Medicine & International …, 2013 - Wiley Online Library
The true incidence of diabetic ketoacidosis (DKA) in sub‐S aharan A frica is unknown but
unlike in the W estern countries, DKA is also uniquely frequent among type 2 diabetes …