Spinal muscular atrophy is a neuromuscular disease resulting from mutations in the SMN1
gene, which encodes the survival motor neuron (SMN) protein. SMN is part of a large …

Although RNA‐binding proteins (RBPs) coordinate many key decisions during cell growth
and differentiation, the dynamics of RNA–RBP interactions have not been extensively …

Knockdown of T-cell intracellular antigens TIA1 and TIAR in transformed cells triggers cell
proliferation and tumor growth. Using a tetracycline-inducible system, we report here that an …

Gene expression patterns vary dramatically in a tissue-specific and age-dependent manner.
RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) critically …

Posttranscriptional regulation is emerging as a key factor in glucocorticoid (GC)-mediated
gene regulation. We investigated the role of the human GC receptor (GR) as an RNA …

T-cell intracellular antigen 1 (TIA1)-related/like (TIAR/TIAL1) protein is a multifunctional RNA-
binding protein (RBP) involved in regulating many aspects of gene expression …

Introduction• Post‐transcriptional gene regulation by hypoxia‐Control of mRNA turnover‐
mRNA decay‐mRNA stabilization‐Control of translation‐Translational inhibition …

T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins
discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the …

TIAR and HuR are mRNA-binding proteins that play important roles in the regulation of
translation. They both possess three RNA recognition motifs (RRMs) and bind to AU-rich …

Multicellular organisms must ensure genome integrity to prevent accumulation of mutations,
cell death, and cancer. The DNA damage response (DDR) is a complex network that …