RIP-Chip Analysis: RNA-Binding Protein Immunoprecipitation-Microarray (Chip) Profiling

R Jain, T Devine, AD George, SV Chittur… - RNA: Methods and …, 2011 - Springer
Post-transcriptional regulation of gene expression plays an important role in complex
cellular processes. Just like transcription factors regulate gene expression through …

Depletion of T-cell intracellular antigen proteins promotes cell proliferation

R Reyes, J Alcalde, JM Izquierdo - Genome biology, 2009 - Springer
Background T-cell intracellular antigen-1 (TIA-1) and TIA-1 related/like protein (TIAR/TIAL1),
two DNA/RNA binding proteins broadly expressed in eukaryotic cells, participate in the …

Identification of a signature motif in target mRNAs of RNA-binding protein AUF1

K Mazan-Mamczarz, Y Kuwano, M Zhan… - Nucleic acids …, 2009 - academic.oup.com
The ubiquitous RNA-binding protein AUF1 promotes the degradation of some target
mRNAs, but increases the stability and translation of other targets. Here, we isolated AUF1 …

Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3′-untranslated region of ataxia telangiectasia mutated and Rad3 …

R Yang, M Zhan, NR Nalabothula, Q Yang… - Journal of Biological …, 2010 - ASBMB
The predominantly nuclear heterogenous ribonucleoprotein A18 (hnRNP A18) translocates
to the cytosol in response to cellular stress and increases translation by specifically binding …

TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway

OR Gottschald, V Malec, G Krasteva… - Journal of molecular …, 2010 - academic.oup.com
T-cell intracellular antigen (TIA)-1 and TIA-1-related protein (TIAR) are mRNA-binding
proteins that can aggregate within granules under specific stress conditions. In this study, we …

Perspectives on the ARE as it turns 25 years old

D Beisang, PR Bohjanen - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
The AU‐rich element (ARE) was discovered in 1986 as a conserved mRNA sequence found
in the 3′ untranslated region of the TNF‐α transcript and other transcripts encoding …

Dr. Jekyll and Mr. Hyde? Physiology and pathology of neuronal stress granules

P Jeon, JA Lee - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Stress granules (SGs) are membraneless cytosolic granules containing dense aggregations
of RNA-binding proteins and RNAs. They appear in the cytosol under stress conditions and …

Role of stress granules in suppressing viral replication by the infectious bronchitis virus endoribonuclease

J Zhao, D Feng, Y Zhao, M Huang, X Zhang… - Journal of …, 2022 - Am Soc Microbiol
Infectious bronchitis virus (IBV), a γ-coronavirus, causes the economically important poultry
disease infectious bronchitis. Cellular stress response is an effective antiviral strategy that …

RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation

T Zhang, H Zheng, D Lu, G Guan, D Li… - … and Targeted Therapy, 2023 - nature.com
The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves not only as a bicistronic
message RNA to translate core protein (Cp) and DNA polymerase (Pol), but also as the …

T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy

C Sanchez-Jimenez, JM Izquierdo - PLoS One, 2013 - journals.plos.org
Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1 related/like protein
(TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these …