RNA m6A methylation across the transcriptome
E Sendinc, Y Shi - Molecular cell, 2023 - cell.com
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Exon architecture controls mRNA m6A suppression and gene expression
N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
Exon junction complex shapes the m6A epitranscriptome
Abstract N6-methyladenosine (m6A), the most abundant modification of mRNA, is essential
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
Abstract N 6-methyladenosine (m6A) methylation can be deposited on chromatin-associated
RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state …
RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state …
Quantitative profiling of pseudouridylation landscape in the human transcriptome
Pseudouridine (Ψ) is an abundant post-transcriptional RNA modification in ncRNA and
mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome …
mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome …
[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis
Light regulates chlorophyll homeostasis and photosynthesis via various molecular
mechanisms in plants. The light regulation of transcription and protein stability of nuclear …
mechanisms in plants. The light regulation of transcription and protein stability of nuclear …