Platelets play a major role in hemostasis as ppwell as in many other physiological and
pathological processes. Accordingly, production of about 1011 platelet per day as well as …

Platelets play a key role in maintaining normal hemostasis and are also recognized as
partners in the development of arterial thrombosis. Today, platelet function testing is used for …

Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …

Background Platelet (PLT) product transfusion is a life-saving therapy for actively bleeding
patients. There is an urgent need to maintain PLT function and extend shelf life to improve …

Background Excessive or abnormal mucocutaneous bleeding (MCB) may impact all aspects
of the physical and psychosocial wellbeing of those who live with it (PWMCB). The evidence …

Aspirin resistance (AR) is a pressing problem in current ischemic stroke care. Although the
role of genetic variations is widely considered, the data still remain controversial. Our aim …

Patients who suffer from inherited or acquired thrombocytopenia can be also affected by
platelet function defects, which potentially increase the risk of severe and life-threatening …

In many patients referred with significant bleeding phenotype, laboratory testing fails to
define any hemostatic abnormalities. Clinical practice with respect to diagnosis and …

Background: Transfusion of platelets is a life-saving medical strategy used worldwide to treat
patients with thrombocytopenia as well as platelet function disorders. Summary: Until the …

Prognosis of patients with HER2+ breast-to-brain-metastasis (BBM) is dismal even after
current standard-of-care treatments, including surgical resection, whole-brain radiation, and …