Flavin dependent monooxygenases
MME Huijbers, S Montersino, AH Westphal… - Archives of biochemistry …, 2014 - Elsevier
Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …
enantioselective oxygenation reactions. As such, they are involved in key biological …
Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis
Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …
The enigmatic reaction of flavins with oxygen
The reaction of flavoenzymes with oxygen remains a fascinating area of research because
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …
Enzymatic strategies for asymmetric synthesis
M Hall - RSC Chemical Biology, 2021 - pubs.rsc.org
Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …
Two-component FAD-dependent monooxygenases: current knowledge and biotechnological opportunities
T Heine, WJH Van Berkel, G Gassner, KH Van Pée… - Biology, 2018 - mdpi.com
Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …
Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and …
J Kratky, D Eggerichs, T Heine… - Angewandte Chemie …, 2023 - Wiley Online Library
Flavoprotein monooxygenases are a versatile group of enzymes for biocatalytic
transformations. Among these, group E monooxygenases (GEMs) catalyze enantioselective …
transformations. Among these, group E monooxygenases (GEMs) catalyze enantioselective …
Mechanisms of reduced flavin transfer in the two-component flavin-dependent monooxygenases
J Sucharitakul, R Tinikul, P Chaiyen - Archives of biochemistry and …, 2014 - Elsevier
Two-component flavin-dependent enzymes are abundant in nature and are involved in a
wide variety of biological reactions. These enzymes consist of a reductase which generates …
wide variety of biological reactions. These enzymes consist of a reductase which generates …
A review: the styrene metabolizing cascade of side-chain oxygenation as biotechnological basis to gain various valuable compounds
M Oelschlägel, J Zimmerling, D Tischler - Frontiers in microbiology, 2018 - frontiersin.org
Styrene is one of the most produced and processed chemicals worldwide and is released
into the environment during widespread processing. But, it is also produced from plants and …
into the environment during widespread processing. But, it is also produced from plants and …
Catalytic and structural features of flavoprotein hydroxylases and epoxidases
S Montersino, D Tischler, GT Gassner… - Advanced Synthesis …, 2011 - Wiley Online Library
Monooxygenases perform chemo‐, regio‐and/or enantioselective oxygenations of organic
substrates under mild reaction conditions. These properties and the increasing number of …
substrates under mild reaction conditions. These properties and the increasing number of …
Biocatalysis as an alternative for the production of chiral epoxides: a comparative review
Enantiopure epoxides are remarkably versatile intermediates for the synthesis of numerous
biologically active targets, to which considerable efforts have been devoted either …
biologically active targets, to which considerable efforts have been devoted either …