Flavin dependent monooxygenases

MME Huijbers, S Montersino, AH Westphal… - Archives of biochemistry …, 2014 - Elsevier
Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …

Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis

CJ Thibodeaux, W Chang, H Liu - Chemical reviews, 2012 - ACS Publications
Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …

The enigmatic reaction of flavins with oxygen

P Chaiyen, MW Fraaije, A Mattevi - Trends in biochemical sciences, 2012 - cell.com
The reaction of flavoenzymes with oxygen remains a fascinating area of research because
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …

Enzymatic strategies for asymmetric synthesis

M Hall - RSC Chemical Biology, 2021 - pubs.rsc.org
Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …

Two-component FAD-dependent monooxygenases: current knowledge and biotechnological opportunities

T Heine, WJH Van Berkel, G Gassner, KH Van Pée… - Biology, 2018 - mdpi.com
Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …

Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and …

J Kratky, D Eggerichs, T Heine… - Angewandte Chemie …, 2023 - Wiley Online Library
Flavoprotein monooxygenases are a versatile group of enzymes for biocatalytic
transformations. Among these, group E monooxygenases (GEMs) catalyze enantioselective …

Mechanisms of reduced flavin transfer in the two-component flavin-dependent monooxygenases

J Sucharitakul, R Tinikul, P Chaiyen - Archives of biochemistry and …, 2014 - Elsevier
Two-component flavin-dependent enzymes are abundant in nature and are involved in a
wide variety of biological reactions. These enzymes consist of a reductase which generates …

A review: the styrene metabolizing cascade of side-chain oxygenation as biotechnological basis to gain various valuable compounds

M Oelschlägel, J Zimmerling, D Tischler - Frontiers in microbiology, 2018 - frontiersin.org
Styrene is one of the most produced and processed chemicals worldwide and is released
into the environment during widespread processing. But, it is also produced from plants and …

Catalytic and structural features of flavoprotein hydroxylases and epoxidases

S Montersino, D Tischler, GT Gassner… - Advanced Synthesis …, 2011 - Wiley Online Library
Monooxygenases perform chemo‐, regio‐and/or enantioselective oxygenations of organic
substrates under mild reaction conditions. These properties and the increasing number of …

Biocatalysis as an alternative for the production of chiral epoxides: a comparative review

H Lin, JY Liu, HB Wang, AAQ Ahmed, ZL Wu - Journal of Molecular …, 2011 - Elsevier
Enantiopure epoxides are remarkably versatile intermediates for the synthesis of numerous
biologically active targets, to which considerable efforts have been devoted either …