Pancreatic beta cell homeostasis is crucial for the synthesis and secretion of insulin;
disruption of homeostasis causes diabetes, and is a treatment target. Adaptation to …

While the consumption of external energy (ie, feeding) is essential to life, this action induces
a temporary disturbance of homeostasis in an animal. A primary example of this effect is …

Routine immunoassays for insulin and C-peptide have the potential to cross-react with
partially processed proinsulin products, although in healthy patients these are present at …

Successful genome editing in primary human islets could reveal features of the genetic
regulatory landscape underlying β cell function and diabetes risk. Here, we describe a …

The islet of Langerhans, functioning as a “mini organ”, plays a vital role in regulating
endocrine activities due to its intricate structure. Dysfunction in these islets is closely …

Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide
(proIAPP), has been reported as an important feature of prediabetes and diabetes …

Biochemical abnormalities in the course of type 1 diabetes (T1D) may cause the
production/activation of various proteins and peptides influencing treatment and causing a …

Aims In recent-onset type 1 diabetes, clamp-derived C-peptide predicts good response to
anti-CD3. Elevated proinsulin and proinsulin/C-peptide ratio (PI/CP) suggest increased …

With the development of modern sequencing techniques and bioinformatics, genomes that
were once thought to be noncoding have been found to encode abundant functional …

Background A hitherto undescribed form of diabetes mellitus type 2 is reported in a Flemish
family. In these patients, markedly elevated gastrin levels were observed, which could not be …