Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

Mast cells are so widely recognized as critical effector cells in allergic disorders and other
immunoglobulin E–associated acquired immune responses that it can be difficult to think of …

▪ Abstract This review focuses on recent progress in our understanding of how mast cells
can contribute to the initiation, development, expression, and regulation of acquired immune …

Stem cell factor (SCF; also known as kit ligand, mast cell ultimate destinations during
development. Hematopoietic cells growth factor, or steel factor) is a hematopoietic cytokine …

In humans and other mammalian species, the pool of resting primordial follicles serves as
the source of developing follicles and fertilizable ova for the entire length of female …

Mice carrying certain mutations in the white spotting (W) locus (ie, c-kit) exhibit reduced c-kit
tyrosine kinase-dependent signaling that results in mast cell deficiency and other phenotypic …

Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice
suggest key roles for mast cells in certain antibody-and T cell-mediated autoimmune …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

ABSTRACT Phospholipase A 2 (PLA 2) plays crucial roles in diverse cellular responses,
including phospholipid digestion and metabolism, host defense and signal transduction …